Why Do We Live Longer When We Eat Less?
Nematode - Key Protease that Activates Autophagy Shows Potential in Antiaging Therapy
Tags: National Yang Ming Chiao Tung University, Taiwan, Healthcare & Lifesciences, Wellness, Safety & Fitness
Scientists have discovered that dietary restriction in nematodes activates autophagy, a cellular process that removes damaged organelles and promotes longevity. The study identified two proteases, SAMS-1 and SET-2, which influence histone methylation and regulate autophagy-related genes. This process extended the nematodes' lifespan by 50-100%. Applications include developing anti-aging drugs that mimic the effects of dietary restriction without needing to reduce food intake. The research offers a molecular target for delaying aging through autophagy modulation.
IP Type or Form Factor: Discovery & Research; Material; Platform
TRL: 3 - proof of concept with needs validated
Industry or Tech Area: Biotechnology; Health & Wellness
