Safer, More Efficient Method for Intracellular Imaging
Metal Chelation-Based Fluorescent Probes for Protein or Other Biomolecule Labeling in Cells
Tags: The University of Hong Kong, Hong Kong, Healthcare & Lifesciences, Energy & Environment
This innovation introduces metal chelation-based fluorescent probes using nickel(II) for imaging His-tagged proteins in live cells, offering higher permeability, lower toxicity, and cost advantages over arsenic-based probes. The technology facilitates the visualization of protein expression and purification, as well as the identification of metalloproteomes, without external chemicals for cell entry. It marks a significant advancement in cell biology and biomedical research, providing a safer, more efficient alternative for intracellular imaging.
IP Type or Form Factor: Patent Granted; Device; Platform
TRL: 6 - prototype validated in intended environment
Industry or Tech Area: Biotechnology; Environment & Sustainability
