Precise Gene Editing with Large DNA Insertion for Therapies
Next Generation Gene Editing Technology
Tags: The University of Sydney, Australia, Healthcare & Lifesciences
Researchers have developed a next-generation gene-editing tool leveraging bacterial transposase enzymes and custom guide RNAs (seekRNA) to achieve highly precise genome modifications. Unlike CRISPR/Cas systems, this technology avoids double-stranded DNA breaks, minimizing off-target mutations and eliminating reliance on error-prone cellular repair mechanisms. It enables the stable insertion of large or multiple DNA sequences, making it ideal for correcting complex genetic disorders. Its adaptability and precision open new possibilities for synthetic biology and therapeutic applications. The technology is protected by an Australian provisional patent and is ready for further development and commercialization.
IP Type or Form Factor: Patent Pending; Platform
TRL: 4 - minimum viable product built in lab
Industry or Tech Area: Biotechnology; Pharmaceutical Engineering
