Novel Method Accelerates Discovery of Antimicrobial Drugs
A Comprehensive Derivative Synthesis Method for Development of New Antimicrobial Drugs
Tags: Hokkaido University, Japan, Healthcare & Lifesciences
Researchers at Hokkaido University have developed a method to streamline the discovery of new antimicrobial drugs by creating a large library of analogs for screening. This approach focuses on splitting known MraY inhibitors into core and accessory regions, which are recombined to generate new candidates. The method identified eight promising analogs, with one demonstrating strong effectiveness against drug-resistant bacteria in mouse models. This platform can be applied to other drug classes, accelerating drug discovery processes. Applications include developing safer, more effective antimicrobials to combat resistant infections.
IP Type or Form Factor: Process & Method; Platform
TRL: 3 - proof of concept with needs validated
Industry or Tech Area: Pharmaceutical Engineering; Biotechnology
