Newly Discovered Protein Improves Efficacy of Nanodrugs
Research on ‘Nanoparticulophagy‘ Overcomes Drug Resistance
Tags: National Yang Ming Chiao Tung University, Taiwan, Healthcare & Lifesciences
NYCU's research team, led by Professor Jui-I Chao, identified the autophagy receptor SQSTM1/p62 as crucial in nanodrug delivery for cancer treatment. This protein regulates the transport and breakdown of nanoparticles in cancer cells, improving the efficacy of nanodrugs and offering hope for overcoming drug resistance. The study specifically enhances the effectiveness of albumin nanodrugs, paving the way for better cancer therapies. Applications include developing more potent nanodrugs for cancers like lung, breast, and pancreatic. The team is now developing a new albumin-bound paclitaxel drug to improve cancer treatment outcomes.
IP Type or Form Factor: Platform
TRL: 4 - minimum viable product built in lab
Industry or Tech Area: Biotechnology; Pharmaceutical Engineering
