Neurons Control Thirst, Salt Intake for New Treatments
Decoding How the Brain Manages the Appetite for Salt and Water
Tags: Tokyo Institute of Technology, Japan, Healthcare & Lifesciences
Researchers at Tokyo Tech have identified specific neurons in the brain's parabrachial nucleus that regulate thirst and salt intake in genetically engineered mice. These neurons act as feedback mechanisms to prevent excessive consumption by activating during ingestion and signaling other brain regions to suppress further intake. Their discovery illuminates the complex neural circuits that manage essential bodily functions and offers insights into diseases caused by abnormal intake behaviors. The technology holds promise for developing new treatments for conditions like polydipsia and salt-sensitive hypertension. Notably, this research helps fill significant gaps in our understanding of how sensory signals from the digestive system influence brain responses before the absorption of water and salt.
IP Type or Form Factor: Discovery & Research
TRL: 3 - proof of concept with needs validated
Industry or Tech Area: Biotechnology; Pharmaceutical Engineering
