Mitochondria-Activated Cells for Regenerative Heart Therapy
Mitochondrial Activation in Transplanted Cells Promotes Regenerative Therapy for Heart Healing
Tags: Hokkaido University, Japan, Healthcare & Lifesciences
Researchers at Hokkaido University developed a technique to enhance heart regeneration by delivering mitochondrial activators to cardiac progenitor cells using MITO-Porter technology. The study found that activating mitochondria in transplanted cells, specifically with Coenzyme Q10 (CoQ10), significantly improved cardiac function and suppressed myocardial fibrosis in rat models of heart failure. The technology could be applied in regenerative therapies for heart disease, with both myocardial and intravenous administration showing promise. Human MITO cells demonstrated higher survival rates and improved metabolic function, suggesting potential for future cardiac therapies. This method opens possibilities for treating severe heart failure more effectively.
IP Type or Form Factor: Material; Process & Method
TRL: 4 - minimum viable product built in lab
Industry or Tech Area: Healthcare Provider; Biotechnology
