Iron-Driven Therapy Targets Colorectal Cancer Progression
Scientists Discover How Excessive Red Meat Consumption Increases Colorectal Cancer Risk
Tags: SingHealth Duke-NUS, Singapore, Healthcare & Lifesciences
A*STAR and the National Cancer Centre Singapore have uncovered a link between high red meat consumption and colorectal cancer through iron’s reactivation of telomerase, which promotes cancer cell growth. This discovery reveals how dietary iron can accelerate cancer progression, offering a pathway to targeted therapies. The team identified SP2509, a small molecule that blocks telomerase reactivation, reducing tumor growth in laboratory tests. This approach could pave the way for therapies that specifically inhibit cancer-driving mechanisms in patients with elevated iron levels. The Colo-SCRIPT program will incorporate these insights to further understand the role of iron in colorectal cancer subtypes, with the aim of improving prevention and treatment.
IP Type or Form Factor: Discovery & Research; Platform
TRL: 3 - proof of concept with needs validated
Industry or Tech Area: Biotechnology; Healthcare Provider
