How Cells Recycling Lipids Help Treat Autophagy Diseases
New Study Sheds Light on the Molecular Mechanisms Underlying Lipid Recycling Within Cells
Tags: Tokyo Institute of Technology, Japan, Healthcare & Lifesciences
Tokyo Tech scientists have advanced our understanding of how cells recycle lipids through autophagy by studying yeast as a model organism. They uncovered the molecular mechanisms by which proteins Atg15, Pep4, and Prb1 interact to degrade phospholipid bilayers in cell membranes. The research reveals that Pep4 and Prb1 activate Atg15, enabling it to break down phospholipids efficiently. This insight has potential applications in treating metabolic disorders and other diseases linked to autophagy. The study provides essential knowledge for targeting lipid recycling in medical research.
IP Type or Form Factor: Discovery & Research
TRL: 2 - technology concept and/or application formulated
Industry or Tech Area: Biotechnology; Pharmaceutical Engineering
