Higher Anti-Tumour Effect with Chemotherapeutic Composition
A Chemotherapeutic Composition for Treating Malignant Tumors and Method for Preparing the Same
Tags: BITS Pilani, India, Healthcare & Lifesciences
The invention involves a chemotherapeutic composition for treating malignant tumors, featuring suberoylanilide hydroxamic acid (SAHA) encapsulated in polymeric micelles made of polyethylene glycol (PEG) and polylactide-co-glycolic acid (PLGA) copolymers. This composition has an encapsulation efficiency of 70-100%, with micelles sized between 50 to 250 nm, improving aqueous solubility and enhancing anti-tumor activity and cytotoxicity compared to the free form of SAHA. The method for preparing this composition involves the copolymers clustering at their hydrophobic PLGA ends to form polymeric micelles. Potential applications include pharmaceutical companies developing nano formulations for cancer therapy.
IP Type or Form Factor: Patent Granted; Platform; Material
TRL: 4 - minimum viable product built in lab
Industry or Tech Area: Biotechnology; Pharmaceutical Engineering
